Sensing Applications of Organic Nanopores

Noah Wilson
UCSC

June 6, 2pm, Engineering 2, Room 486

ABSTRACT

This talk will describe the nanopore test setup as well as survey results obtained by Mark Akeson and Amit Meller from several different experiments, making clear the nanopore's potential for quick and affordable sequencing. A potential applied to the pore creates an electric field which can be used to pull various molecules, such as RNA and DNA, through the pore. The blockage created in the pore by the presence of these molecules causes a change in the ionic current traveling across the pore and can be sensed using a patch-clamp amplifier, which is also used for actuation. Our goal is to use an FPGA to apply feedback control to the pore to automate the detection of bases and other signals of interest. One possible direction is to use iterative learning control (ILC) for the open-loop sensing of enzyme function.

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